Acute optic neuritis: A virological study in relation to multiple sclerosis
Identifieur interne : 002A99 ( Main/Exploration ); précédent : 002A98; suivant : 002B00Acute optic neuritis: A virological study in relation to multiple sclerosis
Auteurs : Daniela Santoli [États-Unis] ; Zofia Wroblewska [États-Unis] ; Natalie E. Cremer [États-Unis] ; Florence S. Lief [États-Unis] ; Norman Schatz [États-Unis]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 1977.
English descriptors
- Teeft :
- Acta neurologica scandinavica, Acute phase, Antibody titers, Body excretions, Brain cells, California state department, Cell cultures, Cell lysates, Cerebrospinal, Cerebrospinal fluid, Control groups, Cytochemical analysis, Diagnostic procedures, Electron microscope, Electron microscopy, England journal, Etiology, Excretion samples, Filament, Fusion technique, Grand island, Health association, Indicator cells, Infectious agents, Infectious virus, Intranuclear, Intranuclear filaments, Koprowski, Lymphocyte, Measles virus, Meulen, Mononuclear, Mononuclear cells, Multiple sclerosis, Negative results, Neuritis, Nikoskelainen, Nuclear changes, Optic, Optic neuritis, Parainfluenza, Parainfluenza type, Peripheral blood, Respiratory syncytial, Rickettsial infections, Room temperature, Santoli, Sclerosis, Serological studies, Serological techniques, Subacute sclerosing panencephalitis, Suitable virological, Systemic lupus erythematosus, Tanaka, Throat swabs, Unusual intranuclear filaments, Viral, Viral agent, Viral antigen, Viral antigens, Viral footprints, Viral origin, Viral particles, Virological, Virological study, Virus antibody levels, Wistar institute.
Abstract
Previous ultrastructural examination of peripheral blood lymphocytes revealed the presence of intranuclear filamentous structures in multiple sclerosis (MS) and in some optic neuritis (ON) patients. The present investigation was undertaken in the attempt to correlate the presence of such structures with the etiology of ON and MS and possibly to demonstrate the viral origin of the filaments. Suitable virological and serological techniques were used to detect and isolate infectious agents from peripheral blood samples and body excretions of 12 monosymptomatic ON patients at their first acute attack. Nevertheless, any efforts to demonstrate the presence of a virus in these patients have been unsuccessful: no evidence of active viral infection was obtained by serological studies of serum and cerebrospinal fluid samples, nor could viral antigens or inclusions be observed by immunofluorescence and cytochemical analysis. Negative results were also obtained from studies performed in parallel on MS patients and various controls. The significance of the failure to isolate infectious agents from either ON and MS patients is discussed.
Url:
DOI: 10.1002/jmv.1890010307
Affiliations:
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Lief</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Schatz, Norman" sort="Schatz, Norman" uniqKey="Schatz N" first="Norman" last="Schatz">Norman Schatz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Wills Eye Hospital, Philadelphia</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">1</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="201">201</biblScope><biblScope unit="page" to="208">208</biblScope><biblScope unit="page-count">8</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1977">1977</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta neurologica scandinavica</term><term>Acute phase</term><term>Antibody titers</term><term>Body excretions</term><term>Brain cells</term><term>California state department</term><term>Cell cultures</term><term>Cell lysates</term><term>Cerebrospinal</term><term>Cerebrospinal fluid</term><term>Control groups</term><term>Cytochemical analysis</term><term>Diagnostic procedures</term><term>Electron microscope</term><term>Electron microscopy</term><term>England journal</term><term>Etiology</term><term>Excretion samples</term><term>Filament</term><term>Fusion technique</term><term>Grand island</term><term>Health association</term><term>Indicator cells</term><term>Infectious agents</term><term>Infectious virus</term><term>Intranuclear</term><term>Intranuclear filaments</term><term>Koprowski</term><term>Lymphocyte</term><term>Measles virus</term><term>Meulen</term><term>Mononuclear</term><term>Mononuclear cells</term><term>Multiple sclerosis</term><term>Negative results</term><term>Neuritis</term><term>Nikoskelainen</term><term>Nuclear changes</term><term>Optic</term><term>Optic neuritis</term><term>Parainfluenza</term><term>Parainfluenza type</term><term>Peripheral blood</term><term>Respiratory syncytial</term><term>Rickettsial infections</term><term>Room temperature</term><term>Santoli</term><term>Sclerosis</term><term>Serological studies</term><term>Serological techniques</term><term>Subacute sclerosing panencephalitis</term><term>Suitable virological</term><term>Systemic lupus erythematosus</term><term>Tanaka</term><term>Throat swabs</term><term>Unusual intranuclear filaments</term><term>Viral</term><term>Viral agent</term><term>Viral antigen</term><term>Viral antigens</term><term>Viral footprints</term><term>Viral origin</term><term>Viral particles</term><term>Virological</term><term>Virological study</term><term>Virus antibody levels</term><term>Wistar institute</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous ultrastructural examination of peripheral blood lymphocytes revealed the presence of intranuclear filamentous structures in multiple sclerosis (MS) and in some optic neuritis (ON) patients. The present investigation was undertaken in the attempt to correlate the presence of such structures with the etiology of ON and MS and possibly to demonstrate the viral origin of the filaments. Suitable virological and serological techniques were used to detect and isolate infectious agents from peripheral blood samples and body excretions of 12 monosymptomatic ON patients at their first acute attack. Nevertheless, any efforts to demonstrate the presence of a virus in these patients have been unsuccessful: no evidence of active viral infection was obtained by serological studies of serum and cerebrospinal fluid samples, nor could viral antigens or inclusions be observed by immunofluorescence and cytochemical analysis. Negative results were also obtained from studies performed in parallel on MS patients and various controls. The significance of the failure to isolate infectious agents from either ON and MS patients is discussed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li></region><settlement><li>Berkeley (Californie)</li><li>Philadelphie</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Santoli, Daniela" sort="Santoli, Daniela" uniqKey="Santoli D" first="Daniela" last="Santoli">Daniela Santoli</name></region><name sortKey="Cremer, Natalie E" sort="Cremer, Natalie E" uniqKey="Cremer N" first="Natalie E." last="Cremer">Natalie E. Cremer</name><name sortKey="Lief, Florence S" sort="Lief, Florence S" uniqKey="Lief F" first="Florence S." last="Lief">Florence S. Lief</name><name sortKey="Santoli, Daniela" sort="Santoli, Daniela" uniqKey="Santoli D" first="Daniela" last="Santoli">Daniela Santoli</name><name sortKey="Schatz, Norman" sort="Schatz, Norman" uniqKey="Schatz N" first="Norman" last="Schatz">Norman Schatz</name><name sortKey="Wroblewska, Zofia" sort="Wroblewska, Zofia" uniqKey="Wroblewska Z" first="Zofia" last="Wroblewska">Zofia Wroblewska</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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